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Description

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery.

- Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects
- Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies
- Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes
- Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)
- Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

  • ISBN13: 9781118788356
  • Publisher: Wiley
  • Pubilcation Year: 2015
  • Format: Hardcover
  • Pages: 00600
Specifications
FormatHardcover
Publication DateFebruary 9, 2015
Pages600
Primary CategoryMedical/Pharmacology

Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs
 by 

Li Di

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