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Coasim is A natural formula that offers a strong line of defense to support joint structure, function and flexibility in dogs of all ages. Glucosamine is a natural substance found in your dog's body, with the highest concentration found in healthy cartilage. Glucosamine has an anti-inflammatory effect, helping to reduce your dog's pain Side effects are very rare Helps restore joint health naturally, increasing mobility Improves lubrication in your dog's joints May reduce or eliminate the need for NSAIDS, which have possible side effects and don't repair the joints, only reduce pain Methylsulfonylmethane (MSM) is a naturally occurring compound found in the body. Supplementing a dogs's diet with additional MSM ensures the ability to synthesize collagen for connective tissue health, maintain membrane flexibility, and promote cell regeneration. Chondroitin is a molecule that occurs naturally in the body. It is a major component of cartilage -- the tough, connective tissue that cushions the joints. National Animal Supplement Council (NASC) approved.