The Design of Biological organisms (forms) are determined by design codes. They are made by invariant proteins. The codes control all regulative processes that are involved in development and differentiation. All structural and functional aspects of a developed organism, the patterns of its reproduction, behavior and the potentials need it for its adaptation are determined by its design code. Design codes cannot tolerate mutations, thus no biological organism can be transformed into another. Mutation of a design code protein can lead to initiation of Cancer. New biological organisms can emerge through reprogramming of an existing design code. Design Code Theory, I hope, encourage the protein-sequence analysts to compare the sequence, the secondary, and tertiary structures of invariant protein to help establish a primary list of design code proteins.