Rollover to Zoom 

|Share:

Description

"Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1" guides the reader though the discovery of CREB3L1 as a membrane-bound transcription factor that prevents the proliferation of virus-infected cells. Upon activation, CREB3L1 is found to block the proliferation of cells infected with diverse DNA and RNA viruses, including murine gamma-herpesvirus 68, HCV, West Nile virus, and Sendai virus. The reader is then lead through the discovery that doxorubicin, a widely used anti-cancer drug, requires CREB3L1 to perform the anti-proliferative function utilized in cancer therapy. Data is presented that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates the regulated intramembrane proteolysis of CREB3L1. This leads to the transcription of anti-proliferative genes that block tumor cell proliferation.
  • ISBN13: 9783659230165
  • Publisher: LAP Lambert Academic Publishing
  • Pubilcation Year: 2012
  • Format: Paperback
  • Pages: 00112
Specifications
FormatPaperback
Publication DateSeptember 4, 2012
Pages112
Primary CategoryMedical/General

Inhibition of Cell Proliferation Through R.I.P. of Creb3l1

Write a Review

Free Shipping over $35 and Free Returns 

$73.43
$0.39 off if you opt out of free returns 
0