TevraPet Activate?II for Extra Large Dogs contains imidacloprid, permethrin and pyriproxyfen ? the active ingredients found in K9 Advantix? II? for dogs*.? This broad spectrum topical not only KILLS but REPEL fleas, flea eggs, ticks & mosquitoes. Activate II for dogs also kills ALL stages of fleas, repels biting flies and kills lice. Only for dogs 7 weeks or older and weighing over 55 lbs.